St. John's Nursing Alumni Association members include graduates from the diploma school and the college of nursing programs. The Alumni Association produces Echo, a newsletter with information about alumni, the college and the Hospital Sisters of St. Francis, twice a year.

This group also sponsors several fundraising activities each year, such as the Alumni Raffle and the Phonathon, to raise funds for student scholarships, faculty development and projects that enhance or improve the student educational experience.

New board members are elected every other year.

Each year, the College joins with the Alumni Association to honor the 10-year, 25-year and 50-year graduates at the annual Alumni Banquet.